Ammonia → 2-{4-[(1-Cyclobutylpiperidin-4-yl)oxy]phenyl}-8-methylquinazolin-4(3H)-one

HRID 2422604노트

반응식

HRID 2422604 반응식
[NH2:1][C:2]1[C:10]([CH3:11])=[CH:9][CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=O.[NH3:12].[CH:13]1([N:17]2[CH2:22][CH2:21][CH:20]([O:23][C:24]3[CH:31]=[CH:30][C:27]([CH:28]=O)=[CH:26][CH:25]=3)[CH2:19][CH2:18]2)[CH2:16][CH2:15][CH2:14]1>>[CH:13]1([N:17]2[CH2:22][CH2:21][CH:20]([O:23][C:24]3[CH:31]=[CH:30][C:27]([C:28]4[NH:12][C:4](=[O:6])[C:3]5[C:2](=[C:10]([CH3:11])[CH:9]=[CH:8][CH:7]=5)[N:1]=4)=[CH:26][CH:25]=3)[CH2:19][CH2:18]2)[CH2:16][CH2:15][CH2:14]1

참가 물질

4

반응물 3

HCID 222AmmoniaHCID 781012-Amino-3-methylbenzoic acidHCID 866244614-[(1-Cyclobutyl-4-piperidinyl)oxy]benzaldehyde

생성물 1

HCID 1354665252-{4-[(1-Cyclobutylpiperidin-4-yl)oxy]phenyl}-8-methylquinazolin-4(3H)-one

실험 절차

The entitled compound was obtained according to the method of Example 15 but starting from 2-amino-3-methylbenzoic acid, ammonia and 4-[(1-cyclobutyl-4-piperidinyl)oxy]benzaldehyde.

후처리

  1. customThe entitled compound was obtained

출처 및 근거

ORD 기록
ord-ea02bf8a3189415c9a2504a8ae37be65
출처 데이터셋
uspto-grants-2011_06
특허 번호
US07960394B2

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