Methylamine → 5-Fluoro-3-methyl-2-[4-(3-pyrrolidin-1-ylpropoxy)phenyl]quinazolin-4(3H)-one
반응식
[NH2:1][C:2]1[CH:10]=[CH:9][CH:8]=[C:7]([F:11])[C:3]=1[C:4]([OH:6])=O.[CH3:12][NH2:13].[N:14]1([CH2:19][CH2:20][CH2:21][O:22][C:23]2[CH:30]=[CH:29][C:26]([CH:27]=O)=[CH:25][CH:24]=2)[CH2:18][CH2:17][CH2:16][CH2:15]1>>[F:11][C:7]1[CH:8]=[CH:9][CH:10]=[C:2]2[C:3]=1[C:4](=[O:6])[N:13]([CH3:12])[C:27]([C:26]1[CH:29]=[CH:30][C:23]([O:22][CH2:21][CH2:20][CH2:19][N:14]3[CH2:18][CH2:17][CH2:16][CH2:15]3)=[CH:24][CH:25]=1)=[N:1]2참가 물질
4
실험 절차
The entitled compound was obtained according to the method of Example 15 but starting from 2-amino-6-fluorobenzoic acid, methylamine and 4-(3-pyrrolidin-1-ylpropoxy)benzaldehyde.
후처리
- customThe entitled compound was obtained