Methylamine → 2-{4-[(1-Cyclobutylpiperidin-4-yl)oxy]phenyl}-3,8-dimethylpyrido[4,3-d]pyrimidin-4(3H)-one

HRID 2422617

반응식

HRID 2422617 반응식
[NH2:1][C:2]1[C:7]([C:8]([OH:10])=O)=[CH:6][N:5]=[CH:4][C:3]=1[CH3:11].[CH3:12][NH2:13].[CH:14]1([N:18]2[CH2:23][CH2:22][CH:21]([O:24][C:25]3[CH:32]=[CH:31][C:28]([CH:29]=O)=[C:27](OC)[CH:26]=3)[CH2:20][CH2:19]2)[CH2:17][CH2:16][CH2:15]1>>[CH:14]1([N:18]2[CH2:23][CH2:22][CH:21]([O:24][C:25]3[CH:32]=[CH:31][C:28]([C:29]4[N:13]([CH3:12])[C:8](=[O:10])[C:7]5[CH:6]=[N:5][CH:4]=[C:3]([CH3:11])[C:2]=5[N:1]=4)=[CH:27][CH:26]=3)[CH2:20][CH2:19]2)[CH2:17][CH2:16][CH2:15]1

참가 물질

4

반응물 3

HCID 6329MethylamineHCID 552829474-Amino-5-methylnicotinic acidHCID 866244624-[(1-Cyclobutylpiperidin-4-yl)oxy]-2-methoxybenzaldehyde

생성물 1

HCID 115965662-{4-[(1-Cyclobutylpiperidin-4-yl)oxy]phenyl}-3,8-dimethylpyrido[4,3-d]pyrimidin-4(3H)-one

실험 절차

The entitled compound was obtained according to the method of Example 15 but starting from 4-amino-5-methylnicotinic acid, methylamine and 4-[(1-cyclobutylpiperidin-4-yl)oxy]-2-methoxybenzaldehyde.

후처리

  1. customThe entitled compound was obtained

출처 및 근거

ORD 기록
ord-2e30f74c69684619a483dba95a25d835
출처 데이터셋
uspto-grants-2011_06
특허 번호
US07960394B2

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