Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 2422709생성일: 2026년 10월 26일
P,P-Diphenylphosphinodithioic acid → 3-Amino-3-[4-(1,1-difluoroethyl)-phenyl]thioacrylamide
https://huagongshe.com/reaction/2422709
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | P,P-Diphenylphosphinodithioic acid | HCID 129564 | — |
| 반응물 | HCID 67179938 | HCID 67179938 | — |
| 용매 | Isopropanol | HCID 3776 | — |
| 용매 | Ethyl Acetate | HCID 8857 | — |
| 생성물 | 3-Amino-3-[4-(1,1-difluoroethyl)-phenyl]thioacrylamide | HCID 86632653 | 67.2% |
반응 단계
Add diphenylphosphinodithioic acid (13.2 g, 52.9 mmol) to a solution of 3-amino-3-[4-(1,1-difluoroethyl)phenyl]acrylonitrile (5.50 g, 26.4 mmol) in propan-2-ol (264 mL). Heat to 45° C. for 4 h. Dilute with EtOAc (400 mL), wash with brine 3× (100 mL), and evaporate. Crystallize from EtOAc/hexane to afford 3-amino-3-[4-(1,1-difluoroethyl)-phenyl]thioacrylamide. Yield: 67.2%. ES-MS: m/e 243.0 (m+1).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US07960419B2 |
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| 출처 데이터셋 | uspto-grants-2011_06 |
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| ORD ID | ord-18afdd9e68fe46b7982c1a289e3bf835 |
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| 출처 메모 | uspto-grants-2011_06 |
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