3-(Trifluoromethyl)aniline → N-(Benzimidazol-2-yl)-3-(trifluoromethyl)aniline

HRID 2423037노트

반응식

HRID 2423037 반응식
Cl[C:2]1[NH:3][C:4]2[CH:10]=[CH:9][CH:8]=[CH:7][C:5]=2[N:6]=1.[F:11][C:12]([F:21])([F:20])[C:13]1[CH:14]=[C:15]([CH:17]=[CH:18][CH:19]=1)[NH2:16]>>[N:6]1[C:5]2[CH:7]=[CH:8][CH:9]=[CH:10][C:4]=2[NH:3][C:2]=1[NH:16][C:15]1[CH:17]=[CH:18][CH:19]=[C:13]([C:12]([F:11])([F:20])[F:21])[CH:14]=1

참가 물질

3

반응물 2

HCID 73753-(Trifluoromethyl)anilineHCID 785722-Chlorobenzimidazole

생성물 1

HCID 923987N-(Benzimidazol-2-yl)-3-(trifluoromethyl)aniline

실험 절차

The title compound was prepared from 2-chlorobenzimidazole and 3-(trifluoromethyl)aniline by Procedure A. The product was isolated by filtration and preparative LCMS to give the title compound as the free base (white solid, mp 160-162° C.). MS(ES+) m/z 278 ([M+1]+, 100).

후처리

  1. customThe product was isolated by filtration and preparative LCMS

출처 및 근거

ORD 기록
ord-5349ac32ae5c490081e1cca39dde2852
출처 데이터셋
uspto-grants-2011_06
특허 번호
US07960561B2

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