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1-{3-Fluoro-4-[(phenylmethyl)oxy]phenyl}-4-hydroxy-1H-indazole-6-carbonitrile → 1-(3-Fluoro-4-hydroxyphenyl)-4-hydroxy-1H-indazole-6-carbonitrile

HRID 2423097
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HRID 2423097 반응식
[F:1][C:2]1[CH:3]=[C:4]([N:16]2[C:24]3[C:19](=[C:20]([OH:27])[CH:21]=[C:22]([C:25]#[N:26])[CH:23]=3)[CH:18]=[N:17]2)[CH:5]=[CH:6][C:7]=1[O:8]CC1C=CC=CC=1>C(O)C.C(OCC)(=O)C.[Pd]>[F:1][C:2]1[CH:3]=[C:4]([N:16]2[C:24]3[C:19](=[C:20]([OH:27])[CH:21]=[C:22]([C:25]#[N:26])[CH:23]=3)[CH:18]=[N:17]2)[CH:5]=[CH:6][C:7]=1[OH:8]
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

5

반응물 1

HCID 1363814381-{3-Fluoro-4-[(phenylmethyl)oxy]phenyl}-4-hydroxy-1H-indazole-6-carbonitrile

생성물 1

HCID 1359103851-(3-Fluoro-4-hydroxyphenyl)-4-hydroxy-1H-indazole-6-carbonitrile수율 42.3%

시약·촉매·용매 3

HCID 23938Palladium촉매HCID 702Ethanol용매HCID 8857Ethyl Acetate용매

실험 절차

A solution of 1-{3-fluoro-4-[(phenylmethyl)oxy]phenyl}-4-hydroxy-1H-indazole-6-carbonitrile (D6) (308 mg, 0.86 mmol) in ethanol (10 mL) and ethyl acetate (10 mL) was hydrogenated in an H-cube over a 10% palladium on charcoal catalyst. The resulting solution was concentrated, dissolved in ethanol then the product purified by silica gel chromatography eluting with 10-100% ethyl acetate in hexane to yield the title compound (E3) (98 mg).

후처리

  1. concentrationThe resulting solution was concentrated
  2. dissolutiondissolved in ethanol
  3. customthe product purified by silica gel chromatography
  4. washeluting with 10-100% ethyl acetate in hexane

출처 및 근거

ORD 기록
ord-840a636cf34b44aa94d7a8ac07143d60
출처 데이터셋
uspto-grants-2011_06
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US07960563B2

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