1-{3,5-Difluoro-4-[(phenylmethyl)oxy]phenyl}-4-hydroxy-1H-indazole-6-carbonitrile → 1-(3,5-Difluoro-4-hydroxyphenyl)-4-hydroxy-1H-indazole-6-carbonitrile

HRID 2423113노트

반응식

HRID 2423113 반응식
[F:1][C:2]1[CH:3]=[C:4]([N:17]2[C:25]3[C:20](=[C:21]([OH:28])[CH:22]=[C:23]([C:26]#[N:27])[CH:24]=3)[CH:19]=[N:18]2)[CH:5]=[C:6]([F:16])[C:7]=1[O:8]CC1C=CC=CC=1>C(OCC)(=O)C.[Pd]>[F:1][C:2]1[CH:3]=[C:4]([N:17]2[C:25]3[C:20](=[C:21]([OH:28])[CH:22]=[C:23]([C:26]#[N:27])[CH:24]=3)[CH:19]=[N:18]2)[CH:5]=[C:6]([F:16])[C:7]=1[OH:8]

참가 물질

4

반응물 1

HCID 1363814391-{3,5-Difluoro-4-[(phenylmethyl)oxy]phenyl}-4-hydroxy-1H-indazole-6-carbonitrile

생성물 1

HCID 1359103821-(3,5-Difluoro-4-hydroxyphenyl)-4-hydroxy-1H-indazole-6-carbonitrile수율 50.6%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 8857Ethyl Acetate용매

실험 절차

A solution of 1-{3,5-difluoro-4-[(phenylmethyl)oxy]phenyl}-4-hydroxy-1H-indazole-6-carbonitrile (D37) (610 mg, 1.617 mmol) in ethyl acetate (50 mL) was passed through the H-cube over a 10% palladium on charcoal catalyst at room temperature and pressure. The filtrate was concentrated and then triturated with dichloromethane and collected by filtration to yield the desired product (E20) (235 mg).

후처리

  1. concentrationThe filtrate was concentrated
  2. customtriturated with dichloromethane
  3. filtrationcollected by filtration

출처 및 근거

ORD 기록
ord-6081ca7767bd4235b16e321c7bd55ef4
출처 데이터셋
uspto-grants-2011_06
특허 번호
US07960563B2

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