4-(Hydroxymethyl)-1-(phenylsulfonyl)-1H-indol-5-ol → 5-Hydroxy-1-(phenylsulfonyl)-1H-indole-4-carbaldehyde

HRID 2423127노트

반응식

HRID 2423127 반응식
[OH:1][CH2:2][C:3]1[C:11]([OH:12])=[CH:10][CH:9]=[C:8]2[C:4]=1[CH:5]=[CH:6][N:7]2[S:13]([C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1)(=[O:15])=[O:14]>C(Cl)Cl.[O-2].[O-2].[Mn+4]>[OH:12][C:11]1[CH:10]=[CH:9][C:8]2[N:7]([S:13]([C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=3)(=[O:15])=[O:14])[CH:6]=[CH:5][C:4]=2[C:3]=1[CH:2]=[O:1]

참가 물질

4

반응물 1

HCID 672416334-(Hydroxymethyl)-1-(phenylsulfonyl)-1H-indol-5-ol2회

생성물 1

HCID 866217145-Hydroxy-1-(phenylsulfonyl)-1H-indole-4-carbaldehyde수율 45.8%

시약·촉매·용매 2

HCID 178418406HCID 178418406, 화합물촉매HCID 6344Dichloromethane용매

실험 절차

4-(Hydroxymethyl)-1-(phenylsulfonyl)-1H-indol-5-ol (Intermediate 9, 439 mg, 1.45 mmol) was dissolved in dry DCM (25 mL) and manganese dioxide (0.75 g, 8.7 mmol) was added all in one portion. The reaction mixture was stirred for 2 hours at room temperature and the mixture was filtered through a pad of silica gel. The filtrate was washed with water (1×), dried (MgSO4) and evaporated to give 0.2 g of an orange solid. MS m/z 302 [M+H]+.

후처리

  1. filtrationthe mixture was filtered through a pad of silica gel
  2. washThe filtrate was washed with water (1×)
  3. dry with materialdried (MgSO4)
  4. customevaporated

출처 및 근거

ORD 기록
ord-eea1c31999ab4cfab4aebdc1df0b6da0
출처 데이터셋
uspto-grants-2011_06
특허 번호
US07960374B2

반응 노트

불러오는 중…