Tetrabutylammonium Fluoride → 3-(2-tert-butylphenyl)-1H-indole
반응식
[C:1]([C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[C:11]1[C:19]2[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=2)[N:13](S(C2C=CC=CC=2)(=O)=O)[CH:12]=1)([CH3:4])([CH3:3])[CH3:2].[F-].C([N+](CCCC)(CCCC)CCCC)CCC>O1CCCC1>[C:1]([C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[C:11]1[C:19]2[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=2)[NH:13][CH:12]=1)([CH3:4])([CH3:2])[CH3:3]참가 물질
4
반응 조건
- 온도
- 100 °C
실험 절차
3-(2-tert-Butylphenyl)-1-(phenylsulfonyl)-1H-indole (172.6 mg, 0.443 mmol) was combined with tetrahydrofuran (2.0 mL) and 1 M tetrabutylammonium fluoride solution (2.21 mL) and heated to 100° C. for 20 minutes. The cooled reaction is charged to a silica gel column and purified by eluting with a gradient of ethyl acetate and hexanes to give 3-(2-tert-butylphenyl)-1H-indole (26.8 mg, 26%) as a colorless solid.