Trifluoroacetic acid → 3-(chlorosulfonyl)-5-fluorobenzoic acid

HRID 2423241노트

반응식

HRID 2423241 반응식
FC(F)(F)C(O)=O.[Cl:8][S:9]([C:12]1[CH:13]=[C:14]([CH:25]=[C:26]([F:28])[CH:27]=1)[C:15]([O:17]CC1C=CC=CC=1)=[O:16])(=[O:11])=[O:10]>>[Cl:8][S:9]([C:12]1[CH:13]=[C:14]([CH:25]=[C:26]([F:28])[CH:27]=1)[C:15]([OH:17])=[O:16])(=[O:10])=[O:11]

참가 물질

3

반응물 2

HCID 6422Trifluoroacetic acidHCID 86632597HCID 86632597, 화합물

생성물 1

HCID 37487043-(chlorosulfonyl)-5-fluorobenzoic acid수율 82.1%

실험 절차

A trifluoroacetic acid (18 mL) solution of benzyl 3-(chlorosulfonyl)-5-fluorobenzoate (2.30 g) was stirred at 60° C. for 18 hours. The oily substance floating on the liquid surface was removed, and the solution part was decanted and evaporated under reduced pressure. Hexane was added to the residue, then this was sonicated for 10 minutes. The resulting solid was collected by filtration to obtain 3-(chlorosulfonyl)-5-fluorobenzoic acid (1.37 g). EI: 238

후처리

  1. customwas removed
  2. customthe solution part was decanted
  3. customevaporated under reduced pressure
  4. additionHexane was added to the residue
  5. customthis was sonicated for 10 minutes
  6. filtrationThe resulting solid was collected by filtration

출처 및 근거

ORD 기록
ord-1918c54b18684f078d51ca859cc9e109
출처 데이터셋
uspto-grants-2011_06
특허 번호
US07960562B2

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