Thionyl Chloride → 3-(Chlorosulfonyl)-5-fluorobenzoyl chloride

HRID 2423242노트

반응식

HRID 2423242 반응식
S(Cl)([Cl:3])=O.[Cl:5][S:6]([C:9]1[CH:10]=[C:11]([CH:15]=[C:16]([F:18])[CH:17]=1)[C:12](O)=[O:13])(=[O:8])=[O:7]>CN(C)C=O>[Cl:5][S:6]([C:9]1[CH:10]=[C:11]([CH:15]=[C:16]([F:18])[CH:17]=1)[C:12]([Cl:3])=[O:13])(=[O:8])=[O:7]

참가 물질

4

반응물 2

HCID 24386Thionyl ChlorideHCID 37487043-(chlorosulfonyl)-5-fluorobenzoic acid

생성물 1

HCID 577806583-(Chlorosulfonyl)-5-fluorobenzoyl chloride수율 100.3%

시약·촉매·용매 1

HCID 6228Dimethylformamide촉매

반응 조건

온도
75 °C

실험 절차

One drop of N,N-dimethylformamide was added to a thionyl chloride (2.03 g) suspension of 3-(chlorosulfonyl)-5-fluorobenzoic acid (1.36 g), followed by stirring at 75° C. for 1 hour. The solvent was evaporated, and this was azeotroped with toluene to obtain 3-(chlorosulfonyl)-5-fluorobenzoyl chloride (1.47 g).

후처리

  1. customThe solvent was evaporated
  2. customthis was azeotroped with toluene

출처 및 근거

ORD 기록
ord-07191da2f9714a3ca3e72711eca565c4
출처 데이터셋
uspto-grants-2011_06
특허 번호
US07960562B2

반응 노트

불러오는 중…