4-Piperidinol, 1-methyl- → HCID 23087228, 화합물

HRID 2423573노트

반응식

HRID 2423573 반응식
[OH:1]C1CCN(C)CC1.FC1C=C(C=CC=1F)C#N.[F:19][C:20]1[CH:21]=[C:22]([CH:25]=[CH:26][C:27]=1[O:28][CH:29]1[CH2:34][CH2:33][N:32]([CH3:35])[CH2:31][CH2:30]1)[C:23]#N>>[F:19][C:20]1[CH:21]=[C:22]([CH:25]=[CH:26][C:27]=1[O:28][CH:29]1[CH2:34][CH2:33][N:32]([CH3:35])[CH2:31][CH2:30]1)[CH:23]=[O:1]

참가 물질

4

반응물 3

HCID 660484-Piperidinol, 1-methyl-HCID 5872033,4-DifluorobenzonitrileHCID 230874123-Fluoro-4-(1-methylpiperidin-4-yloxy)benzonitrile

생성물 1

HCID 23087228HCID 23087228, 화합물

실험 절차

Synthesized from 4-hydroxy-1-methylpiperidine and 3,4-difluorobenzonitrile according to an analogous synthetic method to Preparation Example 15, 3-fluoro-4-(1-methylpiperidin-4-yloxy)benzonitrile (1.1 g) was used according to an analogous synthetic method to Preparation Example 16 to provide the title compound (1.1 g).

후처리

  1. customwas used according to an analogous synthetic method to Preparation Example 16

출처 및 근거

ORD 기록
ord-7da41b010ebd47aab4379e8fc531c776
출처 데이터셋
uspto-grants-2011_06
특허 번호
US07960412B2

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