Tetrabutylammonium Fluoride → 1-(1-Ethoxymethyl-4-hydroxymethyl-1H-imidazol-2-yl)ethanone

HRID 242372

반응식

HRID 242372 반응식
[CH2:1]([O:3][CH2:4][N:5]1[CH:9]=[C:8]([CH2:10][O:11][Si](CC)(CC)CC)[N:7]=[C:6]1[C:19](=[O:21])[CH3:20])[CH3:2].[F-].C([N+](CCCC)(CCCC)CCCC)CCC>C1COCC1>[CH2:1]([O:3][CH2:4][N:5]1[CH:9]=[C:8]([CH2:10][OH:11])[N:7]=[C:6]1[C:19](=[O:21])[CH3:20])[CH3:2]

참가 물질

4

반응물 2

HCID 2724141Tetrabutylammonium FluorideHCID 710871971-[1-Ethoxymethyl-4-(triethylsilyloxymethyl)-1H-imidazol-2-yl]ethanone

생성물 1

HCID 682719271-(1-Ethoxymethyl-4-hydroxymethyl-1H-imidazol-2-yl)ethanone

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

The compound (520 mg) obtained in (4) was dissolved in THF (10 mL), followed by addition of tetrabutylammonium fluoride (TBAF, 1.0 M THF solution, 3.32 mL) under stirring, and the stirring was continued for 1 hour. The reaction solution was concentrated under reduced pressure, and the resulting residue was purified by flash chromatography (ethyl acetate/hexane=25%→100%) using amino column (product name: SNAP Cartridge KP-NH 55 g, manufactured by Biotage, Ltd.) to afford the title compound (288 mg).

후처리

  1. concentrationThe reaction solution was concentrated under reduced pressure
  2. customthe resulting residue was purified by flash chromatography (ethyl acetate/hexane=25%→100%)

출처 및 근거

ORD 기록
ord-6d331297395d4da8b63cfab11b23c446
출처 데이터셋
uspto-grants-2014_02
특허 번호
US08653126B2

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