(S)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-5-methyl-3-(2,4,5-trifluorophenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine-1-carboxamide → HCID 46863444, 화합물

HRID 242459

반응식

HRID 242459 반응식
[CH3:1][C:2]([CH3:31])([CH3:30])[C@H:3]([NH:8][C:9]([N:11]1[C:19]2[CH2:18][CH2:17][N:16]([CH3:20])[CH2:15][C:14]=2[C:13]([C:21]2[CH:26]=[C:25]([F:27])[C:24]([F:28])=[CH:23][C:22]=2F)=[N:12]1)=[O:10])[C:4]([NH:6][CH3:7])=[O:5].FC1C=C(C2C3CN(C([O:51][C:52](C)([CH3:54])[CH3:53])=O)CCC=3NN=2)C=CC=1F>>[F:27][C:25]1[CH:26]=[C:21]([C:13]2[C:14]3[CH2:15][N:16]([CH3:20])[CH2:17][CH2:18][C:19]=3[N:11]([C:9]([NH:8][C@@H:3]([C:2]([CH3:30])([CH3:31])[CH3:1])[C:4]([N:6]3[CH2:7][CH2:54][C@H:52]([OH:51])[CH2:53]3)=[O:5])=[O:10])[N:12]=2)[CH:22]=[CH:23][C:24]=1[F:28]

참가 물질

3

반응물 2

HCID 46863441(S)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-5-methyl-3-(2,4,5-trifluorophenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine-1-carboxamideHCID 59345327tert-butyl 3-(3,4-difluorophenyl)-6,7-dihydro-1H-pyrazolo[4,3-c]pyridine-5(4H)-carboxylate

생성물 1

HCID 46863444HCID 46863444, 화합물

실험 절차

Compound 47 was prepared according to the procedure described for the synthesis of compound 37 by replacing intermediate 19 with intermediate 15, and replacing tert-leucine methylamide with intermediate 25. LCMS (+ESI) m/z=476.3 [M+H]+.

출처 및 근거

ORD 기록
ord-4d5635156dbc47a98976a3309ff556ac
출처 데이터셋
uspto-grants-2014_02
특허 번호
US08653127B2

연결된 노트

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