5-amino-1-(2-methoxyphenyl)-1H-pyrazole-4-carboxamide → 5-Amino-1-(4,4-difluorocyclohexyl)-1h-pyrazole-4-carboxamide

HRID 2424785노트

반응식

HRID 2424785 반응식
NC1N(C2C=CC=CC=2[O:13]C)N=CC=1C(N)=O.[NH2:18][C:19]1[N:23]([CH:24]2[CH2:29][CH2:28][C:27]([F:31])([F:30])[CH2:26][CH2:25]2)[N:22]=[CH:21][C:20]=1[C:32]#[N:33]>>[NH2:18][C:19]1[N:23]([CH:24]2[CH2:29][CH2:28][C:27]([F:31])([F:30])[CH2:26][CH2:25]2)[N:22]=[CH:21][C:20]=1[C:32]([NH2:33])=[O:13]

참가 물질

3

반응물 2

HCID 121517035-amino-1-(2-methoxyphenyl)-1H-pyrazole-4-carboxamideHCID 584166835-Amino-1-(4,4-difluorocyclohexyl)-1h-pyrazole-4-carbonitrile

생성물 1

HCID 575562475-Amino-1-(4,4-difluorocyclohexyl)-1h-pyrazole-4-carboxamide

실험 절차

Following the procedure for the preparation of 5-amino-1-(2-methoxyphenyl)-1H-pyrazole-4-carboxamide but substituting 5-amino-1-(4,4-difluorocyclohexyl)-1H-pyrazole-4-carbonitrile provided the title compound. 400 MHz 1H NMR (CD3OD) δ 8.01 (s, 1H), 4.19 (m, 1H), 2.22-1.90 (m, 8H).

출처 및 근거

ORD 기록
ord-f4dc4744a05f4deb8d31d5edca11d1ec
출처 데이터셋
uspto-grants-2011_06
특허 번호
US07964607B2

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