5-amino-1-(2-methoxyphenyl)-1H-pyrazole-4-carboxamide → 5-amino-1-cyclobutyl-1H-pyrazole-4-carboxamide

반응식

[NH2:1][C:2]1[N:6]([C:7]2[CH:12]=[CH:11][CH:10]=CC=2OC)[N:5]=[CH:4][C:3]=1[C:15]([NH2:17])=[O:16].NC1N(C2CCC2)N=CC=1C#N>>[NH2:1][C:2]1[N:6]([CH:7]2[CH2:12][CH2:11][CH2:10]2)[N:5]=[CH:4][C:3]=1[C:15]([NH2:17])=[O:16]

참가 물질

반응물 2

HCID 121517035-amino-1-(2-methoxyphenyl)-1H-pyrazole-4-carboxamide

HCID 498535445-amino-1-cyclobutyl-1H-pyrazole-4-carbonitrile

생성물 1

HCID 575563275-amino-1-cyclobutyl-1H-pyrazole-4-carboxamide

실험 절차

Following the procedure for the preparation of 5-amino-1-(2-methoxyphenyl)-1H-pyrazole-4-carboxamide but substituting 5-amino-1-cyclobutyl-1H-pyrazole-4-carbonitrile provided the title compound. 400 MHz 1H NMR (CD3OD) δ 7.71 (s, 1H), 4.71-4.55 (m, 1H), 2.61-2.50 (m,2H), 2.46-2.31 (m, 2H), 1.89-1.83 (m, 2H).

출처 및 근거

ORD 기록: ord-16208427a5c64492910d363fb4b3edcc
출처 데이터셋: uspto-grants-2011_06
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07964607B2

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