1,3-Dibromopropane → Ethyl 1-pyridin-3-ylcyclobutane-1-carboxylate

반응식

[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([CH2:7][C:8]([O:10][CH2:11][CH3:12])=[O:9])[CH:2]=1.Br[CH2:14][CH2:15][CH2:16]Br>>[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([C:7]2([C:8]([O:10][CH2:11][CH3:12])=[O:9])[CH2:16][CH2:15][CH2:14]2)[CH:2]=1

참가 물질

반응물 2

HCID 80011,3-Dibromopropane

HCID 96490Ethyl 3-pyridylacetate

생성물 1

HCID 67246748Ethyl 1-pyridin-3-ylcyclobutane-1-carboxylate

실험 절차

Prepared in a similar manner to that described above by reacting ethyl 2-pyridin-3-ylacetate with 1,3-dibromopropane to give ethyl 1-pyridin-3-ylcyclobutane-1-carboxylate which was then hydrogenated to give the desired compound as a brown oil (quantitative reaction).

후처리

customPrepared in a similar manner to that

출처 및 근거

ORD 기록: ord-f374677e9bf0408cab463ad44f34a638
출처 데이터셋: uspto-grants-2011_06
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07964618B2

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