1-(Thiazol-2-yl)piperazine → (S)-3-(3,4-difluorophenyl)-N-(3,3-dimethyl-1-oxo-1-(4-(thiazol-2-yl)piperazin-1-yl)butan-2-yl)-6,7-dihydropyrano[4,3-c]pyrazole-1(4H)-carboxamide

참여 물질

역할	이름	HCID	투입량
반응물	1-(Thiazol-2-yl)piperazine	HCID 911806	—
반응물	(S)-N-(1-(2-cyanoethylamino)-3,3-dimethyl-1-oxobutan-2-yl)-3-(3,4-difluorophenyl)-6,7-dihydropyrano[4,3-c]pyrazole-1(4H)-carboxamide	HCID 46862252	—
생성물	(S)-3-(3,4-difluorophenyl)-N-(3,3-dimethyl-1-oxo-1-(4-(thiazol-2-yl)piperazin-1-yl)butan-2-yl)-6,7-dihydropyrano[4,3-c]pyrazole-1(4H)-carboxamide	HCID 46862248	—

반응 단계

Compound 108 was prepared by the procedure described for the synthesis of compound 104 by replacing 2-cyanoethylamine with 2-(piperazin-1-yl)thiazole. LCMS (+ESI) m/z=545.3 [M+H]+. 1H NMR (CDCl3) δ 7.93 (d, J=9.6 Hz, 1H), 7.48-7.52 (m, 1H), 7.30-7.32 (m, 1H), 7.19-7.26 (m, 2H), 6.63 (d, J=3.7 Hz, 1H), 4.87 (d, J=9.6 Hz, 1H), 4.82 (s, 2H), 3.87-3.98 (m, 4H), 3.64-3.81 (m, 3H), 3.45-3.58 (m, 3H), 3.18 (br, 2H), 1.11 (s, 9H).

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US08653127B2
출처 데이터셋	uspto-grants-2014_02
ORD ID	ord-ed51f6f8257949be9ba9fe135eb41797
출처 메모	uspto-grants-2014_02