4-Fluorohippuric acid → 4-fluoro-N-(2-oxo-2-(phenyl(3-(trifluoromethyl)phenyl)methylamino)ethyl)benzamide

반응식

[F:1][C:2]1[CH:14]=[CH:13][C:5]([C:6]([NH:8][CH2:9][C:10]([OH:12])=O)=[O:7])=[CH:4][CH:3]=1.[C:15]1([CH:21]([NH2:32])[C:22]2[CH:27]=[CH:26][CH:25]=[C:24]([C:28]([F:31])([F:30])[F:29])[CH:23]=2)[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1>>[F:1][C:2]1[CH:3]=[CH:4][C:5]([C:6]([NH:8][CH2:9][C:10](=[O:12])[NH:32][CH:21]([C:15]2[CH:16]=[CH:17][CH:18]=[CH:19][CH:20]=2)[C:22]2[CH:27]=[CH:26][CH:25]=[C:24]([C:28]([F:29])([F:30])[F:31])[CH:23]=2)=[O:7])=[CH:13][CH:14]=1

참가 물질

반응물 2

HCID 6993414-Fluorohippuric acid

HCID 21528802Phenyl(3-(trifluoromethyl)phenyl)methanamine

생성물 1

HCID 248999954-fluoro-N-(2-oxo-2-(phenyl(3-(trifluoromethyl)phenyl)methylamino)ethyl)benzamide

실험 절차

Prepared in analogy to example 1.1 from (4-fluoro-benzoylamino)-acetic acid (CA [366-79-0]) and rac-C-phenyl-C-(3-trifluoromethyl-phenyl)-methylamine (CA [70428-92-1]). MS (m/e): 429.4 (MH−, 100%).

출처 및 근거

ORD 기록: ord-1c91cc83172042f793d5e1c0d2de7597
출처 데이터셋: uspto-grants-2011_06
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07964645B2

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