HCID 67180429, 화합물 → Methyl 2-(4-(1-aminoethyl)-5-methyl-1H-pyrazol-1-yl)acetate dihydrochloride

HRID 2425548노트

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HRID 2425548 반응식
[ClH:1].Cl.[CH3:3][N:4]1[C:8]([CH3:9])=[C:7]([C@H:10]([NH2:12])[CH3:11])[CH:6]=[N:5]1.C(C1C=NN(C[C:23]([O:25][CH3:26])=[O:24])C=1C)(=O)C>>[ClH:1].[ClH:1].[NH2:12][CH:10]([C:7]1[CH:6]=[N:5][N:4]([CH2:3][C:23]([O:25][CH3:26])=[O:24])[C:8]=1[CH3:9])[CH3:11]

참가 물질

3

반응물 2

HCID 67180429HCID 67180429, 화합물HCID 67181907Methyl 2-(4-acetyl-5-methyl-1H-pyrazol-1-yl)acetate

생성물 1

HCID 67181378Methyl 2-(4-(1-aminoethyl)-5-methyl-1H-pyrazol-1-yl)acetate dihydrochloride수율 6.6%

실험 절차

The title compound was prepared in 6.6% yield by the process as described for (R)-1-(1,5-dimethyl-1H-pyrazol-4-yl)ethanamine dihydrochloride (Amine 2) using methyl 2-(4-acetyl-5-methyl-1H-pyrazol-1-yl)acetate (Step A8A) as a starting material. 1H NMR (300 MHz, DMSO-d5) δ 1.48 (3H, d, J=6.0 Hz), 2.22 (3H, s), 3.69 (3H, s), 4.29-4.33 (1H, m), 5.05 (2H, s), 7.59 (1H, s), 8.26 (3H, brs).

출처 및 근거

ORD 기록
ord-72e19205a5a14bc5b43cdfcd270bcfd3
출처 데이터셋
uspto-grants-2011_06
특허 번호
US07964732B2

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