1-(2-Methanesulfonylethyl)piperazine dihydrochloride → [(4S,5R)-2-(4-tert-Butyl-2-ethoxy-phenyl)-4,5-bis-(4-chloro-phenyl)-4,5-dihydro-imidazol-1-yl]-[4-(2-methanesulfonyl-ethyl)-piperazin-1-yl]-methanone hydrochloride

참여 물질

역할	이름	HCID	투입량
반응물	1-(2-Methanesulfonylethyl)piperazine dihydrochloride	HCID 17749885	—
반응물	(4S,5R)-2-(4-tert-butyl-2-ethoxy-phenyl)-4,5-bis-(4-chloro-phenyl)-4,5-dihydro-imidazole-1-carbonyl chloride	HCID 57732375	—
생성물	[(4S,5R)-2-(4-tert-Butyl-2-ethoxy-phenyl)-4,5-bis-(4-chloro-phenyl)-4,5-dihydro-imidazol-1-yl]-[4-(2-methanesulfonyl-ethyl)-piperazin-1-yl]-methanone hydrochloride	HCID 11563923	—

반응 단계

[(4S,5R)-2-(4-tert-Butyl-2-ethoxy-phenyl)-4,5-bis-(4-chloro-phenyl)-4,5-dihydro-imidazol-1-yl-]-[4-(2-methanesulfonyl-ethyl)-piperazin-1-yl]-methanone hydrochloride was prepared from (4S,5R)-2-(4-tert-butyl-2-ethoxy-phenyl)-4,5-bis-(4-chloro-phenyl)-4,5-dihydro-imidazole-1-carbonyl chloride (example 11) and 1-(2-methanesulfonylethyl)piperazine dihydrochloride (example 17) in an analogous manner as described in example 25. LR-MS: 685.3 [(M+H)+]

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US07964724B2
출처 데이터셋	uspto-grants-2011_06
ORD ID	ord-8f610c47422a4a3cbe0aa8548ed00849
출처 메모	uspto-grants-2011_06