N,N-dimethyl-2-(piperazin-1-yl)acetamide → 2-{4-[(4S,5R)-2-(4-tert-Butyl-2-ethoxy-phenyl)-4,5-bis-(4-chloro-phenyl)-4,5-dihydro-imidazole-1-carbonyl]-piperazin-1-yl}-N,N-dimethyl-acetamide hydrochloride

참여 물질

역할	이름	HCID	투입량
반응물	N,N-dimethyl-2-(piperazin-1-yl)acetamide	HCID 2758642	—
반응물	(4S,5R)-2-(4-tert-butyl-2-ethoxy-phenyl)-4,5-bis-(4-chloro-phenyl)-4,5-dihydro-imidazole-1-carbonyl chloride	HCID 57732375	—
생성물	2-{4-[(4S,5R)-2-(4-tert-Butyl-2-ethoxy-phenyl)-4,5-bis-(4-chloro-phenyl)-4,5-dihydro-imidazole-1-carbonyl]-piperazin-1-yl}-N,N-dimethyl-acetamide hydrochloride	HCID 67012901	—

반응 단계

2-{4-[(4S,5R)-2-(4-tert-Butyl-2-ethoxy-phenyl)-4,5-bis-(4-chloro-phenyl)-4,5-dihydro-imidazole-1-carbonyl]-piperazin-1-yl}-N,N-dimethyl-acetamide hydrochloride was prepared from (4S,5R)-2-(4-tert-butyl-2-ethoxy-phenyl)-4,5-bis-(4-chloro-phenyl)-4,5-dihydro-imidazole-1-carbonyl chloride (example 11) and N,N-dimethyl-2-piperazin-1-yl-acetamide (Oakwood Products) in an analogous manner as described in example 25. LR-MS: 664.4 [(M+H)+]

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US07964724B2
출처 데이터셋	uspto-grants-2011_06
ORD ID	ord-cf8c7cb35310432b8a7b5b4aac489a13
출처 메모	uspto-grants-2011_06