N-isopropyl-N-methyl-2-piperazin-1-yl-acetamide → 2-{4-[(4S,5R)-2-(4-tert-Butyl-5-chloro-2-ethoxy-phenyl)-4,5-bis-(4-chloro-phenyl)-4,5-dihydro-imidazole-1-carbonyl]-piperazin-1-yl}-N-isopropyl-N-methyl-acetamide hydrochloride

참여 물질

역할	이름	HCID	투입량
반응물	N-isopropyl-N-methyl-2-piperazin-1-yl-acetamide	HCID 28378703	—
반응물	(4S,5R)-2-(4-tert-butyl-5-chloro-2-ethoxy-phenyl)-4,5-bis-(4-chloro-phenyl)-4,5-dihydro-imidazole-1-carbonyl chloride	HCID 86602324	—
생성물	2-{4-[(4S,5R)-2-(4-tert-Butyl-5-chloro-2-ethoxy-phenyl)-4,5-bis-(4-chloro-phenyl)-4,5-dihydro-imidazole-1-carbonyl]-piperazin-1-yl}-N-isopropyl-N-methyl-acetamide hydrochloride	HCID 11578605	—

반응 단계

2-{4-[(4S,5R)-2-(4-tert-Butyl-5-chloro-2-ethoxy-phenyl)-4,5-bis-(4-chloro-phenyl)-4,5-dihydro-imidazole-1-carbonyl]-piperazin-1-yl}-N-isopropyl-N-methyl-acetamide hydrochloride was prepared from (4S,5R)-2-(4-tert-butyl-5-chloro-2-ethoxy-phenyl)-4,5-bis-(4-chloro-phenyl)-4,5-dihydro-imidazole-1-carbonyl chloride (example 12h) and N-isopropyl-N-methyl-2-piperazin-1-yl-acetamide (example 16c) in an analogous manner as described in example 25. LR-MS: 728.4 [(M+H)+]

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US07964724B2
출처 데이터셋	uspto-grants-2011_06
ORD ID	ord-9315c8326a664dcfa2f88a4c3bc49945
출처 메모	uspto-grants-2011_06