Ammonium Hydroxide → 1-Benzyl-4-[(4-chlorophenyl)amino]piperidine-4-carboxamide

HRID 242573노트

반응식

HRID 242573 반응식
[CH2:1]([N:8]1[CH2:13][CH2:12][C:11]([NH:16][C:17]2[CH:22]=[CH:21][C:20]([Cl:23])=[CH:19][CH:18]=2)([C:14]#[N:15])[CH2:10][CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[OH-:24].[NH4+]>S(=O)(=O)(O)O>[CH2:1]([N:8]1[CH2:9][CH2:10][C:11]([NH:16][C:17]2[CH:18]=[CH:19][C:20]([Cl:23])=[CH:21][CH:22]=2)([C:14]([NH2:15])=[O:24])[CH2:12][CH2:13]1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

참가 물질

4

반응물 2

HCID 14923Ammonium HydroxideHCID 704181-Benzyl-4-((4-chlorophenyl)amino)piperidine-4-carbonitrile

생성물 1

HCID 705871-Benzyl-4-[(4-chlorophenyl)amino]piperidine-4-carboxamide수율 71%

시약·촉매·용매 1

HCID 1118Sulfuric Acid용매

실험 절차

To 1-Benzyl-4-(4-chloro-phenylamino)-piperidine-4-carbonitrile (1.97 g, 6.05 mmol) was added concentrated sulfuric acid (50 ml). The reaction stirred at room temperature as an orange homogeneous solution. After 24 hours the reaction was cooled to 0° C. and very slowly poured into concentrated ammonium hydroxide in ice. The precipitate was filtered and washed with water to give a white solid (202 mg, 71%).

후처리

  1. temperatureAfter 24 hours the reaction was cooled to 0° C.
  2. filtrationThe precipitate was filtered
  3. washwashed with water

출처 및 근거

ORD 기록
ord-472db5c21c164fca93c386677e549843
출처 데이터셋
uspto-grants-2014_02
특허 번호
US08653096B2

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