4-(4-Chloro-phenyl)-3-methyl-piperazine-1-carboxylic acid tert-butyl ester → 1-(4-Chlorophenyl)-2-methylpiperazine

HRID 242613노트

반응식

HRID 242613 반응식
C(OC([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[CH:19]=[CH:18][C:17]([Cl:20])=[CH:16][CH:15]=2)[CH:10]([CH3:21])[CH2:9]1)=O)(C)(C)C>Cl.O1CCOCC1>[Cl:20][C:17]1[CH:16]=[CH:15][C:14]([N:11]2[CH2:12][CH2:13][NH:8][CH2:9][CH:10]2[CH3:21])=[CH:19][CH:18]=1

참가 물질

3

반응물 1

HCID 667579574-(4-Chloro-phenyl)-3-methyl-piperazine-1-carboxylic acid tert-butyl ester

생성물 1

HCID 982891-(4-Chlorophenyl)-2-methylpiperazine

시약·촉매·용매 1

HCID 204431481,4-Dioxane hydrochloride용매

실험 절차

4-(4-Chloro-phenyl)-3-methyl-piperazine-1-carboxylic acid tert-butyl ester (0.83 g, 0.68 mmol) was dissolved in HCl/dioxane (4M, 8 mL) and stirred for 2 hr at rt. The mixture was then evaporated in vacuo, basified with aqueous sodium hydroxide (1M, 50 mL), and extracted with ethyl acetate (3×100 mL). The organic layers were evaporated and the crude residue used in the next step, (0.56 g, brown oil)

후처리

  1. customThe mixture was then evaporated in vacuo
  2. extractionextracted with ethyl acetate (3×100 mL)
  3. customThe organic layers were evaporated

출처 및 근거

ORD 기록
ord-39fa8889025d47899e53e3f3ac467a7f
출처 데이터셋
uspto-grants-2014_02
특허 번호
US08653096B2

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