Trifluoroacetic acid → (2,7-Dioxo-5,6,7,8-tetrahydro-4H-imidazo[1,5,4-fg][1,6]-benzodiazocin-1(2H)-yl)acetic Acid
반응식
[O:1]=[C:2]1[CH:16]([CH2:17][C:18]([O:20]C(C)(C)C)=[O:19])[C:15]2[N:14]=[CH:13][N:6]3[CH2:7][C:8](=[O:12])[CH2:9][CH2:10][NH:11][C:4]([C:5]=23)=[CH:3]1.C(O)(C(F)(F)F)=O>C(Cl)Cl>[O:1]=[C:2]1[CH:16]([CH2:17][C:18]([OH:20])=[O:19])[C:15]2[N:14]=[CH:13][N:6]3[CH2:7][C:8](=[O:12])[CH2:9][CH2:10][NH:11][C:4]([C:5]=23)=[CH:3]1참가 물질
4
실험 절차
To a solution of tert-butyl (2,7-dioxo-5,6,7,8-tetrahydro-4H-imidazo[1,5,4-fg][1,6]benzodiazocin-1(2H)-yl)acetate from Step D (15 mg, 0.045 mmol) in CH2Cl2 (3 mL) was added TFA (1 mL). After 2 h, the mixture was concentrated under reduced pressure to give the title compound. MS: m/z=276 (M+1).
후처리
- concentrationthe mixture was concentrated under reduced pressure
출처 및 근거
- ORD 기록
- ord-e5db2a5460a643f4ba4e530e1d5ea114
- 출처 데이터셋
- uspto-grants-2011_06
- 특허 번호
- US07968540B2
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