Methanol → Methyl 3-(benzyloxy)-4-oxo-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidine-2-carboxylate

HRID 2426256

반응식

HRID 2426256 반응식
Cl.[NH:2]=[C:3]1[CH2:8][CH2:7][CH2:6][CH2:5][NH:4]1.[O:9]=[C:10](CC([O-])=O)[C:11]([O-:13])=O.[CH2:18]1[CH2:28][CH2:27]N2[C:21](=NCCC2)[CH2:20][CH2:19]1.C[CH2:30][O:31][C:32]([CH3:34])=[O:33].[CH3:35]O>>[CH2:35]([O:13][C:11]1[C:10](=[O:9])[N:4]2[CH2:5][CH2:6][CH2:7][CH2:8][C:3]2=[N:2][C:34]=1[C:32]([O:31][CH3:30])=[O:33])[C:21]1[CH:20]=[CH:19][CH:18]=[CH:28][CH:27]=1

참가 물질

6

반응물 5

HCID 887MethanolHCID 8857Ethyl AcetateHCID 811841,8-Diazabicyclo(5.4.0)undec-7-eneHCID 164550OxalacetateHCID 178479080HCID 178479080, 화합물

생성물 1

HCID 59771042Methyl 3-(benzyloxy)-4-oxo-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidine-2-carboxylate

실험 절차

Commercially available 2-iminopiperidine hydrochloride (1.5 eq) was added at room temperature to a solution of oxosuccinate prepared in Step 1 b (1 eq) in MeOH. After dropwise addition of neat DBU (4.5 eq), the reaction mixture was stirred for 2 days. Evaporation of the solvent gave a residue that was taken into EtOAc and washed with 1N HCl and brine; the organic layer was dried on Na2SO4 and the solvent removed. The crude was used without further purification.

후처리

  1. customEvaporation of the solvent
  2. customgave a residue that
  3. washwashed with 1N HCl and brine
  4. customthe organic layer was dried on Na2SO4
  5. customthe solvent removed
  6. customThe crude was used without further purification

출처 및 근거

ORD 기록
ord-cadc7bedb6f049e8ac365a03c6d488fa
출처 데이터셋
uspto-grants-2011_06
특허 번호
US07968553B2

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