Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
4-(2,5,6-Trichloro-pyrimidin-4-ylamino)-piperidine-1-carboxylic acid tert-butyl ester → Piperidin-4-yl-(2,5,6-trichloro-pyrimidin-4-yl)-amine dihydrochloride
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 4-(2,5,6-Trichloro-pyrimidin-4-ylamino)-piperidine-1-carboxylic acid tert-butyl ester | HCID 86618554 | — |
| 용매 | Hydrochloric Acid | HCID 313 | — |
| 용매 | 1,4-Dioxane | HCID 31275 | — |
| 생성물 | Piperidin-4-yl-(2,5,6-trichloro-pyrimidin-4-yl)-amine dihydrochloride | HCID 86618555 | — |
반응 단계
A solution of 4-(2,5,6-trichloro-pyrimidin-4-ylamino)-piperidine-1-carboxylic acid tert-butyl ester (0.85 g, 2.23 mmol) in 4 M HCl in dioxane (100 mL) was stirred at rt for 2 h. The solvent was removed under reduced pressure and the crude product used in the consecutive step without further purification assuming quantitative deprotection and formation of the dihydrochloride salt. MS (ISP): 283.4 [M+H]+.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07968568B2 |
| 출처 데이터셋 | uspto-grants-2011_06 |
| ORD ID | ord-1c680eb52f654c44a994710335b912cf |
| 출처 메모 | uspto-grants-2011_06 |