Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Potassium Carbonate → 3-(4-Chloro-benzylamino)-pyrrolidine-1-carboxylic acid tert-butyl ester
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | 1-(Bromomethyl)-4-chlorobenzene | HCID 69329 | — |
| 반응물 | (R)-(+)-1-Boc-3-aminopyrrolidine | HCID 854070 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | 3-(4-Chloro-benzylamino)-pyrrolidine-1-carboxylic acid tert-butyl ester | HCID 66757670 | — |
반응 단계
(R)-3-amino-1-N-Boc pyrrolidine (1.0 eq, 2.68 mmol), 4-chlorobenzyl bromide (1.0 eq, 2.68 mmol), and potassium carbonate (1.75 eq) were mixed in ethanol (10 mL) and the resulting mixture was stirred at room temperature overnight. The reaction mixture was concentrated in vacuo, taken up in ethyl acetate, filtered and concentrated. The crude product was purified by flash chromatography on silica using ethyl acetate.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08653096B2 |
| 출처 데이터셋 | uspto-grants-2014_02 |
| ORD ID | ord-1943e3afa75146d8b29b7c9408767e0b |
| 출처 메모 | uspto-grants-2014_02 |