2,5-Dichlorobenzonitrile → 1-(4-Chloro-2-cyanophenyl)piperidine-4-carboxylic Acid [4-(3-dimethylaminopyrrolidin-1-yl)phenyl]amide

HRID 2426699

반응식

HRID 2426699 반응식
[CH3:1][N:2]([CH3:23])[CH:3]1[CH2:7][CH2:6][N:5]([C:8]2[CH:13]=[CH:12][C:11]([NH:14][C:15]([CH:17]3[CH2:22][CH2:21][NH:20][CH2:19][CH2:18]3)=[O:16])=[CH:10][CH:9]=2)[CH2:4]1.Cl[C:25]1[CH:32]=[CH:31][C:30]([Cl:33])=[CH:29][C:26]=1[C:27]#[N:28]>>[CH3:1][N:2]([CH3:23])[CH:3]1[CH2:7][CH2:6][N:5]([C:8]2[CH:9]=[CH:10][C:11]([NH:14][C:15]([CH:17]3[CH2:22][CH2:21][N:20]([C:25]4[CH:32]=[CH:31][C:30]([Cl:33])=[CH:29][C:26]=4[C:27]#[N:28])[CH2:19][CH2:18]3)=[O:16])=[CH:12][CH:13]=2)[CH2:4]1

참가 물질

3

반응물 2

HCID 890002,5-DichlorobenzonitrileHCID 67147939HCID 67147939, 화합물

생성물 1

HCID 588677651-(4-Chloro-2-cyanophenyl)piperidine-4-carboxylic Acid [4-(3-dimethylaminopyrrolidin-1-yl)phenyl]amide

실험 절차

Piperidine-4-carboxylic acid [4-(3-dimethylaminopyrrolidin-1-yl)phenyl]amide was reacted with 2,5-dichlorobenzonitrile as described in example 323. This resulted in the product with the molecular weight of 452.00 (C25H30CIN5O); MS (ESI): 452 (M+H+).

후처리

  1. customThis resulted in the product with the molecular weight of 452.00 (C25H30CIN5O)

출처 및 근거

ORD 기록
ord-fdc40c582f2c4fe0bbc596f9e63bb0d8
출처 데이터셋
uspto-grants-2011_06
특허 번호
US07968550B2

연결된 노트

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