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Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 2426707생성일: 2026년 10월 27일

Cyclobutanone → tert-Butyl (R)-[1-(2-Fluoro-4-cyclobutylaminophenyl)pyrrolidin-3-yl]methylcarbamate

https://huagongshe.com/reaction/2426707

반응식

참여 물질

역할이름HCID투입량
반응물CyclobutanoneHCID 14496—
반응물TriacetoxyborohydrideHCID 2724942—
반응물tert-Butyl (R)-[1-(4-amino-2-fluorophenyl)pyrrolidin-3-yl]methylcarbamateHCID 68988249—
생성물tert-Butyl (R)-[1-(2-Fluoro-4-cyclobutylaminophenyl)pyrrolidin-3-yl]methylcarbamateHCID 86594882—

반응 단계

tert-Butyl (R)-[1-(4-amino-2-fluorophenyl)pyrrolidin-3-yl]methylcarbamate was alkylated with cyclobutanone using triacetoxyborohydride as reducing agent by method N. This resulted in the product with the molecular weight of 363.48 (C20H30FN3O2); MS (ESI): 364 (M+H+).

출처 및 근거

DOI10.6084/m9.figshare.5104873.v1
특허 번호US07968550B2
출처 데이터셋uspto-grants-2011_06
ORD IDord-07e9dd52e18c463ab234649294923abb
출처 메모uspto-grants-2011_06