Trifluoroacetic acid → 2-[(4-Chloro-benzyl)-pyrrolidin-3-yl-amino]ethanol

HRID 242683노트

반응식

HRID 242683 반응식
C(OC([N:8]1[CH2:12][CH2:11][CH:10]([N:13]([CH2:17][C:18]2[CH:23]=[CH:22][C:21]([Cl:24])=[CH:20][CH:19]=2)[CH2:14][CH2:15][OH:16])[CH2:9]1)=O)(C)(C)C.FC(F)(F)C(O)=O>ClCCl>[Cl:24][C:21]1[CH:20]=[CH:19][C:18]([CH2:17][N:13]([CH:10]2[CH2:11][CH2:12][NH:8][CH2:9]2)[CH2:14][CH2:15][OH:16])=[CH:23][CH:22]=1

참가 물질

4

반응물 2

HCID 6422Trifluoroacetic acidHCID 667586553-[(4-Chloro-benzyl)-(2-hydroxy-ethyl)-amino]-pyrrolidine-1-carboxylic acid tert-butyl ester

생성물 1

HCID 231368872-[(4-Chloro-benzyl)-pyrrolidin-3-yl-amino]ethanol

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

A solution of 3-[(4-chloro-benzyl)-(2-hydroxy-ethyl)-amino]-pyrrolidine-1-carboxylic acid tert-butyl ester (0.22 g, 0.6 mmol) in dichloromethane cooled at 0° C. was treated with trifluoroacetic acid (20%). The resulting mixture was warmed to room temperature and stirred for 2 h. The reaction mixture was concentrated in vacuo, diluted with ethyl acetate and free based with 10% aqueous sodium bicarbonate. The combined organics were dried over sodium sulfate. The product was used without any further purification. ESI-MS m/z:255 (M+1), UV retention time: 0.34 min.

후처리

  1. concentrationThe reaction mixture was concentrated in vacuo
  2. additiondiluted with ethyl acetate
  3. dry with materialThe combined organics were dried over sodium sulfate
  4. customThe product was used without any further purification

출처 및 근거

ORD 기록
ord-5ba7a3dd8f764449af40040a3e667675
출처 데이터셋
uspto-grants-2014_02
특허 번호
US08653096B2

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