2-Propenoic acid, 2-(bromomethyl)-, methyl ester → Methyl 3-methoxy-2-(methoxymethyl)propanoate

HRID 2426961노트

반응식

HRID 2426961 반응식
[CH3:1][O-:2].[Na+].[CH3:4][OH:5].Br[CH2:7][C:8](=[CH2:13])[C:9]([O:11][CH3:12])=[O:10]>CO>[CH3:1][O:2][CH2:7][CH:8]([CH2:13][O:5][CH3:4])[C:9]([O:11][CH3:12])=[O:10]

참가 물질

4

반응물 2

HCID 5210932-Propenoic acid, 2-(bromomethyl)-, methyl esterHCID 23694274Sodium methanolate methanol

생성물 1

HCID 22934772Methyl 3-methoxy-2-(methoxymethyl)propanoate수율 82%

시약·촉매·용매 1

HCID 887Methanol용매2회

실험 절차

To a 28% sodium methoxide/methanol solution (4.24 g) in methanol (35 mL) was added methyl 2-(bromomethyl)acrylate (1.79 g) in methanol (10 mL). The mixture was stirred at room temperature for 2 hours and was heated to reflux for 3 hours. The reaction mixture was poured into 2N hydrochloric acid-ice, then extracted with ethyl acetate. The obtained organic layer was washed with brine, dried and concentrated to give the title compound (1.33 g) having the following physical data.

후처리

  1. temperaturewas heated
  2. temperatureto reflux for 3 hours
  3. extractionextracted with ethyl acetate
  4. washThe obtained organic layer was washed with brine
  5. customdried
  6. concentrationconcentrated

출처 및 근거

ORD 기록
ord-02fbfe27c3224d6db8ec9becf126b0d5
출처 데이터셋
uspto-grants-2011_06
특허 번호
US07968572B2

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