2-Bromobenzaldehyde → Ethyl 3-(3-formylphenyl)but-2-enoate

HRID 242704

반응식

Br[C:2]1[CH:9]=[CH:8][CH:7]=[CH:6][C:3]=1[CH:4]=[O:5].[C:10]([O:15][CH2:16][CH3:17])(=[O:14])/[CH:11]=[CH:12]/[CH3:13]>>[CH:4]([C:3]1[CH:6]=[C:7]([C:12]([CH3:13])=[CH:11][C:10]([O:15][CH2:16][CH3:17])=[O:14])[CH:8]=[CH:9][CH:2]=1)=[O:5]

참가 물질

반응물 2

HCID 811292-Bromobenzaldehyde

HCID 429065Ethyl trans-crotonate

생성물 1

HCID 86632145Ethyl 3-(3-formylphenyl)but-2-enoate

실험 절차

Coupling of 3 bromobenzaldehyde with ethyl crotonate following the method used in Example 26 gave ethyl 3-(3-formylphenyl)but-2-enoate as a light yellow oil Yield (0.547, 23%): 1H NMR (300 MHz, CDCl3) δ 10.05 (s, 1H), 7.99 (t, J=1.6 Hz, 1H), 7.87 (dt, J=7.6, 1.3 Hz, 1H), 7.74 (m, 1H), 7.56 (t, J=7.6 Hz, 1H), 6.19 (q, J=1.2 Hz, 1H), 4.23 (q, J=7.2 Hz, 2H), 2.61 (d, J=1.2 Hz, 3H), 1.33 (t, J=7.2 Hz, 3H).

출처 및 근거

ORD 기록: ord-4eafe148bfb64c0180d50c20141135fb
출처 데이터셋: uspto-grants-2014_02
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08653142B2

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