Ethanol → Ethyl 2-methoxyimino-5-methyl-4-oxohexanoate

HRID 2427061노트

반응식

HRID 2427061 반응식
[OH:1][C:2]([CH:11]([CH3:13])[CH3:12])=[CH:3][C:4](=O)[C:5]([O:7][CH2:8][CH3:9])=[O:6].Cl.[CH3:15][O:16][NH2:17].C(O)C>C(OCC)(=O)C>[CH3:15][O:16][N:17]=[C:4]([CH2:3][C:2](=[O:1])[CH:11]([CH3:13])[CH3:12])[C:5]([O:7][CH2:8][CH3:9])=[O:6]

참가 물질

5

반응물 3

HCID 702EthanolHCID 521874O-Methylhydroxylamine hydrochlorideHCID 178473097HCID 178473097, 화합물

생성물 1

HCID 86632548Ethyl 2-methoxyimino-5-methyl-4-oxohexanoate수율 92%

시약·촉매·용매 1

HCID 8857Ethyl Acetate용매

실험 절차

A mixture of 5.0 g of ethyl 4-hydroxy-5-methyl-2-oxo-3-hexenoate, 2.46 g of O-methylhydroxylamine hydrochloride and 10 ml of ethanol was stirred at room temperature for 6 hours. After ethyl acetate was poured into the reaction mixture, the organic layer was washed with water and an aqueous saturated sodium chloride solution, dried over anhydrous magnesium sulfate, and concentrated under reduced pressure to obtain 5.32 g of ethyl 2-methoxyimino-5-methyl-4-oxohexanoate of the formula:

후처리

  1. washthe organic layer was washed with water
  2. dry with materialan aqueous saturated sodium chloride solution, dried over anhydrous magnesium sulfate
  3. concentrationconcentrated under reduced pressure

출처 및 근거

ORD 기록
ord-a923c9a1a1ed4a699366518304057969
출처 데이터셋
uspto-grants-2011_06
특허 번호
US07968573B2

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