Ethanol → 3-[2,5-Dioxo-4-[(2-propenyloxy)methyl]imidazolidin-4-yl]benzonitrile

HRID 2427148노트

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HRID 2427148 반응식
[CH2:1]([O:4][CH2:5][C:6]([C:8]1[CH:15]=[CH:14][CH:13]=[CH:12][C:9]=1C#N)=O)[CH:2]=[CH2:3].O.[C-:17]#[N:18].[K+].[C:20](=[O:23])([O-])[O-].[NH4+:24].[NH4+:25].C[CH2:27][OH:28]>>[O:28]=[C:27]1[NH:25][C:6]([C:8]2[CH:9]=[C:12]([CH:13]=[CH:14][CH:15]=2)[C:17]#[N:18])([CH2:5][O:4][CH2:1][CH:2]=[CH2:3])[C:20](=[O:23])[NH:24]1

참가 물질

6

반응물 5

HCID 702EthanolHCID 962WaterHCID 9032Potassium CyanideHCID 517111Ammonium CarbonateHCID 86641460(2-(2-Propenyloxy)acetyl]benzonitrile

생성물 1

HCID 671310093-[2,5-Dioxo-4-[(2-propenyloxy)methyl]imidazolidin-4-yl]benzonitrile

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온도
55 °C

실험 절차

To a solution of 450 mg of 3-[(2-(2-propenyloxy)acetyl]benzonitrile (in EtOH (5 mL) and water (5 mL) 291 mg of potassium cyanide and ammonium carbonate are added. The mixture is refluxed one night at 55° C. The mixture is extracted with ethyl acetate, dried over magnesium sulfate and concentrated under vacuum to give the desired compound.

후처리

  1. extractionThe mixture is extracted with ethyl acetate
  2. dry with materialdried over magnesium sulfate
  3. concentrationconcentrated under vacuum

출처 및 근거

ORD 기록
ord-6a5bfc1d08ce4aa281846337c9f5e2d7
출처 데이터셋
uspto-grants-2011_06
특허 번호
US07968581B2

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