Diphenylsilane → 4-(4-Bromo-3-fluorobenzyl)morpholine

HRID 2427455

반응식

HRID 2427455 반응식
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([N:10]2[CH2:15][CH2:14][O:13][CH2:12][CH2:11]2)=O)=[CH:4][C:3]=1[F:16].C1([SiH2]C2C=CC=CC=2)C=CC=CC=1>C1COCC1.C=O.C1C=CC(P(C2C=CC=CC=2)C2C=CC=CC=2)=CC=1.C1C=CC(P(C2C=CC=CC=2)C2C=CC=CC=2)=CC=1.C1C=CC(P(C2C=CC=CC=2)C2C=CC=CC=2)=CC=1.[Rh]>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][N:10]2[CH2:11][CH2:12][O:13][CH2:14][CH2:15]2)=[CH:4][C:3]=1[F:16]

참가 물질

5

반응물 2

HCID 69888DiphenylsilaneHCID 48474115(4-Bromo-3-fluorophenyl)(morpholin-4-yl)methanone

생성물 1

HCID 534178184-(4-Bromo-3-fluorobenzyl)morpholine

시약·촉매·용매 2

HCID 53249357Carbonyltris(triphenylphosphine)rhodium(I)hydride촉매HCID 8028Tetrahydrofuran용매

실험 절차

A 250 ml flask was charged with (4-bromo-3-fluorophenyl)(morpholino)methanone (4.569 g, 15.86 mmol) and dissolved in 16 mL of THF. Diphenylsilane (6.2 ml, 33.4 mmol) was added followed by carbonyltris(triphenylphosphine)rhodium(I)hydride (100 mg, 0.109 mmol) and the reaction stirred at room temperature for 20 hours.

출처 및 근거

ORD 기록
ord-194f609a09f74839a2fb9bc9ea0c0080
출처 데이터셋
uspto-grants-2011_06
특허 번호
US07968574B2

연결된 노트

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