Methanol → Methyl 2-chloro-6-methylbenzoate

HRID 2427579노트

반응식

HRID 2427579 반응식
[Cl:1][C:2]1[CH:10]=[CH:9][CH:8]=[C:7]([CH3:11])[C:3]=1[C:4]([OH:6])=[O:5].[C:12](Cl)(=O)C(Cl)=O.CO.C(N(CC)CC)C>ClCCl.CN(C)C=O>[CH3:12][O:5][C:4](=[O:6])[C:3]1[C:7]([CH3:11])=[CH:8][CH:9]=[CH:10][C:2]=1[Cl:1]

참가 물질

7

반응물 4

HCID 887MethanolHCID 8471TriethylamineHCID 65578Oxalyl chlorideHCID 888702-Chloro-6-methylbenzoic acid

생성물 1

HCID 22935202Methyl 2-chloro-6-methylbenzoate

시약·촉매·용매 2

HCID 6228Dimethylformamide촉매HCID 6344Dichloromethane용매

실험 절차

A solution of 2-chloro-6-methyl-benzoic acid (1.70 g, 10 mmol)) in dichloromethane (10 mL) was treated with oxalyl chloride (6 mL, 12 mmol) and dimethylformamide (several drops) followed by treatment with methanol (10 mL) and triethylamine (2.78 mL, 20 mmol). Workup afforded 2-chloro-6-methyl-benzoic acid methyl ester. The material was used without further purification.

출처 및 근거

ORD 기록
ord-82c26bd18e6249b995a2ff8741fe69c1
출처 데이터셋
uspto-grants-2011_06
특허 번호
US07968570B2

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