참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Ethyl Acetate | HCID 8857 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | Methyl 2-(bromomethyl)benzoate | HCID 2734813 | — |
| 반응물 | 3-(2-Chlorophenyl)propan-1-amine | HCID 5200411 | — |
| 용매 | Toluene | HCID 1140 | — |
| 용매 | Hexane | HCID 8058 | — |
| 생성물 | 2-[3-(2-Chloro-phenyl)-propyl]-2,3-dihydro-isoindol-1-one | HCID 57949485 | 53.2% |
반응 단계
A mixture of 2-bromomethyl-benzoic acid methyl ester (0.115 g, 0.5 mmol), 3-(2-chloro-phenyl)-propylamine (0.102 g, 0.6 mmol), and K2CO3 (0.207 g, 1.5 mmol) in toluene (3 mL) was heated with stirring at 100° C. for 2 h. Workup and silica gel column chromatography using 30% ethyl acetate in hexane afforded 2-[3-(2-chloro-phenyl)-propyl]-2,3-dihydro-isoindol-1-one (0.076 g, 51%). 1H NMR (300 MHz, CDCl3): δ (ppm) 1.99 (m, 2H), 2.79 (t, 2H), 3.69 (t, 2H), 4.41 (s, 2H), 7.14-7.58 (m, 7H), 7.88 (d, 1H). GC-MS: m/z 285 (M)+.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US07968570B2 |
|---|
| 출처 데이터셋 | uspto-grants-2011_06 |
|---|
| ORD ID | ord-1df23dae3caa47be968028c3a305f6bd |
|---|
| 출처 메모 | uspto-grants-2011_06 |
|---|
