m-Chloroperbenzoic acid → Methyl thieno[3,4-b]thiophene-2-carboxylate

HRID 242764노트

반응식

HRID 242764 반응식
[CH3:1][O:2][C:3]([C:5]1[S:9][C:8]2[CH2:10][S:11][CH2:12][C:7]=2[CH:6]=1)=[O:4].C1C=C(Cl)C=C(C(OO)=O)C=1>C(OCC)(=O)C.C(=O)=O>[S:9]1[C:5]([C:3]([O:2][CH3:1])=[O:4])=[CH:6][C:7]2=[CH:12][S:11][CH:10]=[C:8]12

참가 물질

5

반응물 2

HCID 70297m-Chloroperbenzoic acidHCID 3441857Methyl 4,6-dihydrothieno[3,4-b]thiophene-2-carboxylate

생성물 1

HCID 19007653Methyl thieno[3,4-b]thiophene-2-carboxylate

시약·촉매·용매 2

HCID 280Carbon Dioxide용매HCID 8857Ethyl Acetate용매2회

실험 절차

A solution of 2.0 g (10 mmol) (3) in 30 mL ethyl acetate was stirred and cooled down in dry ice bath. MCPBA (1.75 g, 10 mmol) in 30 mL ethyl acetate was added dropwise to the reaction solution. After the addition, the mixture was kept stirring for overnight. Then the solvent was removed by evaporation and the residue contained a crude product of (4) and 3-chlorobenzoic acid.

후처리

  1. additionAfter the addition
  2. customThen the solvent was removed by evaporation

출처 및 근거

ORD 기록
ord-c57d31ad389d49c883de7ca97a887f21
출처 데이터셋
uspto-grants-2014_02
특허 번호
US08653228B2

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