Benzoyl Peroxide → 2-Bromomethyl-4,6-dichlorobenzoic acid methyl ester

HRID 2427750노트

반응식

HRID 2427750 반응식
[CH3:1][O:2][C:3](=[O:13])[C:4]1[C:9]([CH3:10])=[CH:8][C:7]([Cl:11])=[CH:6][C:5]=1[Cl:12].[Br:14]NC(=O)CCC(N)=O.C(OOC(=O)C1C=CC=CC=1)(=O)C1C=CC=CC=1>C(Cl)(Cl)(Cl)Cl>[CH3:1][O:2][C:3](=[O:13])[C:4]1[C:5]([Cl:12])=[CH:6][C:7]([Cl:11])=[CH:8][C:9]=1[CH2:10][Br:14]

참가 물질

5

반응물 3

HCID 7187Benzoyl PeroxideHCID 9834204N-BromosuccinamideHCID 57949430Methyl 2,4-dichloro-6-methylbenzoate

생성물 1

HCID 579493492-Bromomethyl-4,6-dichlorobenzoic acid methyl ester

시약·촉매·용매 1

HCID 5943Carbon Tetrachloride용매

실험 절차

A mixture of 2,4-dichloro-6-methyl-benzoic acid methyl ester (0.71 g, 3.23 mmol), N-bromosuccinamide (0.693 g, 3.9 mmol), and benzoyl peroxide (0.012 g, 0.05 mmol) in carbon tetrachloride (20 mL) was heated at reflux until majority of ester was consumed (as analyzed by GC/MS). The resulting mixture was filtered, the filtrate was concentrated to afford 2-Bromomethyl-4,6-dichloro-benzoic acid methyl ester. The material was used without further purification.

후처리

  1. temperaturewas heated
  2. customwas consumed (as analyzed by GC/MS)
  3. filtrationThe resulting mixture was filtered
  4. concentrationthe filtrate was concentrated

출처 및 근거

ORD 기록
ord-d02f25935f2e4e34831f30b3de573bff
출처 데이터셋
uspto-grants-2011_06
특허 번호
US07968570B2

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