Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Thionyl Chloride → Hydrochloric Acid
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Thionyl Chloride | HCID 24386 | — |
| 반응물 | 2-Hydroxy-5-nitrobenzyl alcohol | HCID 2763823 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | Hydrochloric Acid | HCID 313 | — |
| 생성물 | 4-Nitrophenol | HCID 980 | — |
반응 단계
The 4-nitro-2-hydroxymethylphenol is then converted to a 2-halomethyl-4-nitrophenol via a mild halogenation reaction such as a thionyl chloride in THF or is produced directly from 4-nitrophenol in a solution of concentrated HCl, a catalytic amount of H2SO4 and formaldehyde dimethylacetal solution by bubbling gaseous HCl through the solution at about 50 to 80° C. (preferably 70° C.) until a thick white precipitate is formed. The thionyl chloride conversion of the 2-hydroxymethyl group is shown process is shown as follows:
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06855833B2 |
| 출처 데이터셋 | uspto-grants-2005_02 |
| ORD ID | ord-0bc3368c4db74dd88c16b51853f605b4 |
| 출처 메모 | uspto-grants-2005_02 |