4-Nitrobenzoic Acid → 4-Nitro-N-(3-(trifluoromethyl)phenyl)benzamide

반응식

[F:1][C:2]([F:11])([F:10])[C:3]1[CH:4]=[C:5]([CH:7]=[CH:8][CH:9]=1)[NH2:6].[N+:12]([C:15]1[CH:23]=[CH:22][C:18]([C:19](O)=[O:20])=[CH:17][CH:16]=1)([O-:14])=[O:13]>>[N+:12]([C:15]1[CH:16]=[CH:17][C:18]([C:19]([NH:6][C:5]2[CH:7]=[CH:8][CH:9]=[C:3]([C:2]([F:10])([F:11])[F:1])[CH:4]=2)=[O:20])=[CH:22][CH:23]=1)([O-:14])=[O:13]

참가 물질

반응물 2

HCID 61084-Nitrobenzoic Acid

HCID 73753-(Trifluoromethyl)aniline

생성물 1

HCID 20622524-Nitro-N-(3-(trifluoromethyl)phenyl)benzamide수율 80%

실험 절차

Using 3-trifluoromethylaniline (1.77 g, 11.0 mmol) and 4-nitrobenzoic acid (1.67 g, 10.0 mmol), the procedure of Reference Example 16 was repeated to obtain 2.48 g (80.0%) of the title compound in the form of colorless powder.

출처 및 근거

ORD 기록: ord-5184ffb1f92a40a8a3af5aec36316d41
출처 데이터셋: uspto-grants-1998_03
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US05728835

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