Ammonium Hydroxide → 2-Oxoindoline-5-sulfonamide

HRID 24310

반응식

HRID 24310 반응식
Cl[S:2]([C:5]1[CH:6]=[C:7]2[C:11](=[CH:12][CH:13]=1)[NH:10][C:9](=[O:14])[CH2:8]2)(=[O:4])=[O:3].[OH-].[NH4+:16]>C(O)C>[NH2:16][S:2]([C:5]1[CH:6]=[C:7]2[C:11](=[CH:12][CH:13]=1)[NH:10][C:9](=[O:14])[CH2:8]2)(=[O:4])=[O:3]

참가 물질

4

반응물 2

HCID 14923Ammonium HydroxideHCID 49625062-oxo-2,3-dihydro-1H-indole-5-sulfonyl chloride

생성물 1

HCID 101982322-Oxoindoline-5-sulfonamide수율 20%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

5-Chlorosulfonyl-2-oxindole (2.1 g) was added to 10 mL of ammonium hydroxide in 10 mL of ethanol and stirred at room temperature overnight. The mixture was concentrated and the solid collected by vacuum filtration to give 0.4 g (20% yield) of the title compound as an off-white solid.

후처리

  1. concentrationThe mixture was concentrated
  2. filtrationthe solid collected by vacuum filtration

출처 및 근거

ORD 기록
ord-2520af5761ac4f8b8d7b07549287ce02
출처 데이터셋
uspto-grants-2005_02
특허 번호
US06855730B2

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