Morpholine → 5-(Morpholinosulfonyl)-2-oxindole
반응식
Cl[S:2]([C:5]1[CH:6]=[C:7]2[C:11](=[CH:12][CH:13]=1)[NH:10][C:9](=[O:14])[CH2:8]2)(=[O:4])=[O:3].[NH:15]1[CH2:20][CH2:19][O:18][CH2:17][CH2:16]1>ClCCl>[O:18]1[CH2:19][CH2:20][N:15]([S:2]([C:5]2[CH:6]=[C:7]3[C:11](=[CH:12][CH:13]=2)[NH:10][C:9](=[O:14])[CH2:8]3)(=[O:4])=[O:3])[CH2:16][CH2:17]1참가 물질
4
실험 절차
A suspension of 2.3 g of 5-chlorosulfonyl-2-oxindole and 2.2 g of morpholine in 50 mL of dichloromethane was stirred at room temperature for 3 hours. The white precipitate was collected by vacuum filtration, washed with ethyl acetate and hexane and dried under vacuum at 40° C. overnight to give 2.1 g (74% yield) of 5-(morpholinosulfonyl)-2-oxindole.
후처리
- filtrationThe white precipitate was collected by vacuum filtration
- washwashed with ethyl acetate and hexane
- customdried under vacuum at 40° C. overnight
출처 및 근거
- ORD 기록
- ord-af5421ae2b654563b186ef26cd4c5d6b
- 출처 데이터셋
- uspto-grants-2005_02
- 특허 번호
- US06855730B2
반응 노트
불러오는 중…