Methyl 2-(2-nitro-4-(trifluoromethyl)phenyl)acetate → 6-Trifluoromethyloxindole

HRID 24314노트

반응식

HRID 24314 반응식
[N+:1]([C:4]1[CH:9]=[C:8]([C:10]([F:13])([F:12])[F:11])[CH:7]=[CH:6][C:5]=1[CH2:14][C:15]([O:17]C)=O)([O-])=O>[Pd]>[F:11][C:10]([F:13])([F:12])[C:8]1[CH:9]=[C:4]2[C:5]([CH2:14][C:15](=[O:17])[NH:1]2)=[CH:6][CH:7]=1

참가 물질

3

반응물 1

HCID 83569Methyl 2-(2-nitro-4-(trifluoromethyl)phenyl)acetate

생성물 1

HCID 6084876-Trifluoromethyloxindole

시약·촉매·용매 1

HCID 23938Palladium촉매

반응 조건

온도
100 °C

실험 절차

Methyl 2-nitro-4-trifluoromethylphenylacetate (26 mg) was hydrogenated over 10% palladium on carbon and then heated at 100° C. for 3 hours. The catalyst was removed by filtration and the solvent evaporated to give the title compound.

후처리

  1. customThe catalyst was removed by filtration
  2. customthe solvent evaporated

출처 및 근거

ORD 기록
ord-7cbd983c068145798984700036a97b65
출처 데이터셋
uspto-grants-2005_02
특허 번호
US06855730B2

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