Acetic Acid → 7-Azaoxindole acetic acid salt

HRID 24321노트

반응식

HRID 24321 반응식
Br[C:2]1(Br)[C:10]2[C:5](=[N:6][CH:7]=[CH:8][CH:9]=2)[NH:4][C:3]1=[O:11].[C:13]([OH:16])(=[O:15])[CH3:14]>C(#N)C.[Zn]>[C:13]([OH:16])(=[O:15])[CH3:14].[NH:4]1[C:5]2[C:10](=[CH:9][CH:8]=[CH:7][N:6]=2)[CH2:2][C:3]1=[O:11]

참가 물질

5

반응물 2

HCID 176Acetic AcidHCID 138640943,3-Dibromo-1H-pyrrolo[2,3-b]pyridin-2(3H)-one

생성물 1

HCID 219257347-Azaoxindole acetic acid salt수율 91%

시약·촉매·용매 2

HCID 23994Zinc촉매HCID 6342Acetonitrile용매

실험 절차

3,3-Dibromo-7-azaoxindole (2.9 g) was dissolved in a mixture of 20 mL of acetic acid and 30 mL of acetonitrile. To the solution was added 6.5 g of zinc dust. The mixture was stirred for 2 hrs at room temperature. The solid was filtered from the mixture and the solvent evaporated. The residue was slurried with ethyl acetate. The ethyl acetate solution containing insoluble solid was passed through a short column of silica gel. The collected ethyl acetate solution was evaporated and the residue dried under vacuum to give 1.8 g (yield 91%) of 7-azaoxindole acetic acid salt.

후처리

  1. filtrationThe solid was filtered from the mixture
  2. customthe solvent evaporated
  3. additionThe ethyl acetate solution containing insoluble solid
  4. customThe collected ethyl acetate solution was evaporated
  5. customthe residue dried under vacuum

출처 및 근거

ORD 기록
ord-93fe4523593c4d208f99e218af9ad7d3
출처 데이터셋
uspto-grants-2005_02
특허 번호
US06855730B2

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