Potassium Hydroxide → 4-(2-carboxyethyl)-2-methyl-1H-pyrrole-3-carboxylic acid

HRID 24328노트

반응식

HRID 24328 반응식
[C:1]([CH2:4][CH2:5][C:6]1[C:7]([C:12]([O:14]CC)=[O:13])=[C:8]([CH3:11])[NH:9][CH:10]=1)([OH:3])=[O:2].[OH-].[K+]>C(O)C>[C:1]([CH2:4][CH2:5][C:6]1[C:7]([C:12]([OH:14])=[O:13])=[C:8]([CH3:11])[NH:9][CH:10]=1)([OH:3])=[O:2]

참가 물질

4

반응물 2

HCID 14797Potassium HydroxideHCID 217287442-Methyl-3-carbethoxy-4-(3-propionic acid)pyrrole

생성물 1

HCID 225710444-(2-carboxyethyl)-2-methyl-1H-pyrrole-3-carboxylic acid수율 64%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

4-(2-Carboxyethyl)-3-ethoxycarbonyl-2-methylpyrrole (Bulter, A. R., and George, S. D. (1993) Tetrahedron 49: 7017-7026) was hydrolyzed using potassium hydroxide (KOH) in ethanol (EtOH) to give 4-(2-carboxyethyl)-2-methyl-1H-pyrrole-3-carboxylic acid (64%).

출처 및 근거

ORD 기록
ord-0e408daf6e994476bc66956e12dee526
출처 데이터셋
uspto-grants-2005_02
특허 번호
US06855730B2

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