P-Anisidine → 4-cyano-N-(4-methoxyphenyl)benzamide

반응식

[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([NH2:9])=[CH:5][CH:4]=1.[C:10]([C:12]1[CH:20]=[CH:19][C:15]([C:16](O)=[O:17])=[CH:14][CH:13]=1)#[N:11]>>[C:10]([C:12]1[CH:20]=[CH:19][C:15]([C:16]([NH:9][C:6]2[CH:7]=[CH:8][C:3]([O:2][CH3:1])=[CH:4][CH:5]=2)=[O:17])=[CH:14][CH:13]=1)#[N:11]

참가 물질

반응물 2

HCID 7732P-Anisidine

HCID 120874-Cyanobenzoic acid

생성물 1

HCID 26650214-cyano-N-(4-methoxyphenyl)benzamide수율 91.7%

실험 절차

Using p-anisidine (1.35 g, 11.0 mmol) and 4-cyanobenzoic acid (1.47 g, 10.0 mmol), the procedure of Reference Example 16 was repeated to obtain 2.31 g (91.7%) of the title compound in the form of colorless needle crystals.

출처 및 근거

ORD 기록: ord-ac9b042f4b28460bbb5f5ac06fb31c97
출처 데이터셋: uspto-grants-1998_03
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US05728835

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