Acetyl chloride → N-(2-Oxoindolin-6-yl)acetamide

HRID 24346노트

반응식

HRID 24346 반응식
[NH2:1][C:2]1[CH:10]=[C:9]2[C:5]([CH2:6][C:7](=[O:11])[NH:8]2)=[CH:4][CH:3]=1.[C:12](Cl)(=[O:14])[CH3:13].C(N(CC)CC)C>ClCCl>[C:12]([NH:1][C:2]1[CH:10]=[C:9]2[C:5]([CH2:6][C:7](=[O:11])[NH:8]2)=[CH:4][CH:3]=1)(=[O:14])[CH3:13]

참가 물질

5

반응물 3

HCID 6367Acetyl chlorideHCID 8471TriethylamineHCID 5905386-Amino-1,3-dihydro-2H-indol-2-one

생성물 1

HCID 2749839N-(2-Oxoindolin-6-yl)acetamide수율 77%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To a mixture of 6-amino-2-oxindole (1 g) and acetyl chloride (0.79 g) in 10 ml of dichloromethane at 0° C. was added triethylamine (1 g). The mixture was brought to room temperature and stirred for 4 hours protected from atmospheric moisture with a dry-tube. The solvent was then evaporated and the residue was recrystallized from methanol to give 0.98 g (77%) of 6-acetylamino-2-oxindole as a beige solid.

후처리

  1. customwas brought to room temperature
  2. customprotected from atmospheric moisture with a dry-tube
  3. customThe solvent was then evaporated
  4. customthe residue was recrystallized from methanol

출처 및 근거

ORD 기록
ord-c74cbbf3ca554b0e8743ea9fb42062a1
출처 데이터셋
uspto-grants-2005_02
특허 번호
US06855730B2

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